| 10 Barrel Brewing Co | 1501 E St | San Diego | California | 92101-6618 | United States | large | |
| 2Kids Brewing Company | 8680 Miralani Dr Ste 123 | San Diego | California | 92126-6391 | United States | micro | |
| 32 North Brewing Co | 8655 Production Ave Ste A | San Diego | California | 92121-2258 | United States | brewpub | |
| Abnormal Beer Company | 16990 Via Tazon Ste 123 | San Diego | California | 92127-1649 | United States | micro | |
| Acoustic Ales Brewing Experiment | 1795 Hancock St Ste P1 | San Diego | California | 92110-2006 | United States | closed | |
| AleSmith Brewing Co | 9990 Alesmith Ct | San Diego | California | 92126-4200 | United States | regional | |
| Align Brewing Co | 8680 Miralani Dr | San Diego | California | 92126-6300 | United States | micro | |
| Alpine Beer Company | 6550 Mira Mesa Blvd | San Diego | California | 92121-4100 | United States | brewpub | |
| Alta Brewing Company | 1983 Julian Avenue | San Diego | California | 92113-1125 | United States | micro | |
| Amplified Ale Works | 4150 Mission Blvd Ste 208 | San Diego | California | 92109-5054 | United States | brewpub | |
| Amplified Ale Works Miramar Studio | 9030 Kenamar Dr Ste 309 | San Diego | California | 92121-2432 | United States | brewpub | |
| Automatic Brewing Co. / Blind Lady Alehouse | 3416 Adams Ave | San Diego | California | 92116-2428 | United States | brewpub | |
| Ballast Point Brewing Co / Home Brew Mart | 5401 Linda Vista Rd Ste 406 | San Diego | California | 92110-2402 | United States | large | |
| Ballast Point Brewing Company | 9045 Carroll Way | San Diego | California | 92121-2405 | United States | large | |
| Ballast Point Brewing Company | 7606 Trade St | San Diego | California | 92121-2405 | United States | large | |
| Ballast Point Brewing Company - Little Italy | 2215 India St | San Diego | California | 92101-1725 | United States | large | |
| Barn Brewery | 2850 El Cajon Blvd Ste 3 | San Diego | California | 92104-1389 | United States | micro | |
| Bay City Brewing Co. | 3760 Hancock St | San Diego | California | 92110 | United States | micro | |
| Benchmark Brewing Co | 6190 Fairmount Ave Ste G | San Diego | California | 92120-3428 | United States | closed | |
| Bitter Brothers Brewing Co. | 4170 Morena Blvd Ste F | San Diego | California | 92117-5252 | United States | micro | |
| Border X Brewing | 2181 Logan Ave | San Diego | California | 92113-2203 | United States | micro | |
| Border X Logan | 2181 Logan Ave | San Diego | California | 92113-2203 | United States | brewpub | |
| California Wild Ales | 4204 Sorrento Valley Blvd | San Diego | California | 92121-1446 | United States | contract | |
| Circle 9 Brewing | 7292 Opportunity Rd Ste C | San Diego | California | 92111-2223 | United States | micro | |
| Circle 9 Brewing | 7292 Opportunity Rd Ste C | San Diego | California | 92111-2223 | United States | closed | |
| Citizen Brewers | 5837 Mission Gorge Rd Ste A | San Diego | California | 92120-4060 | United States | micro | |
| Constellation Brands | 9045 Caroll Way | San Diego | California | 92121 | United States | closed | |
| Coronado Brewing Co - Production Facility | 170 Orange Ave | San Diego | California | 92118-1409 | United States | regional | |
| Council Brewing - Magic Factory | 7705 Convoy Ct | San Diego | California | 92111-1113 | United States | micro | |
| Council Brewing Company | 7705 Convoy Ct | San Diego | California | 92111-1105 | United States | micro | |
| Deft Brewing | 5328 Banks St | San Diego | California | 92110-4008 | United States | micro | |
| Division 23 Brewing | 7408 Trade St | San Diego | California | 92121-3415 | United States | micro | |
| Duck Foot Brewing Co. | 8920 Kenamar Dr Ste 210 | San Diego | California | 92121-2454 | United States | micro | |
| Eppig Brewing | 3052 El Cajon Blvd Ste 103 | San Diego | California | 92104-1399 | United States | micro | |
| Fall Brewing Company | 4542 30th St | San Diego | California | 92116-4247 | United States | micro | |
| G8 Development, Inc. | | San Diego | California | 92109-2802 | United States | planning | |
| Globier | | San Diego | California | 92117-1604 | United States | planning | |
| Gordon Biersch Brewery Restaurant - San Diego | 5010 Mission Center Rd | San Diego | California | 92108-3211 | United States | brewpub | |
| Green Flash Brewing Co | 6550 Mira Mesa Blvd | San Diego | California | 92121-4100 | United States | regional | |
| Half Door Brewing Company | 903 Island Ave | San Diego | California | 92101-7227 | United States | brewpub | |
| Helm's Brewing Company, LLC | 5640 Kearny Mesa Rd Ste C | San Diego | California | 92111-1312 | United States | closed | |
| Hillcrest Brewing Company | 1458 University Ave | San Diego | California | 92103-3405 | United States | brewpub | |
| Hodad's Brewing Company | | San Diego | California | 92123 | United States | planning | |
| Home Brewing Co. | 2911 El Cajon Blvd # 2 | San Diego | California | 92104-1204 | United States | micro | |
| Intergalactic Brewing Co | 9715 Carroll Centre Rd #107 | San Diego | California | 92126-6507 | United States | micro | |
| Karl Strauss Brewing Co | 5985 Santa Fe St | San Diego | California | 92109-1623 | United States | regional | |
| Karl Strauss Brewing Co - 4S Ranch | 10448 Reserve Dr | San Diego | California | 92127-3510 | United States | brewpub | |
| Karl Strauss Brewing Co - Downtown | 1157 Columbia St | San Diego | California | 92101-3511 | United States | brewpub | |
| Karl Strauss Brewing Co - Sorrento Mesa | 9675 Scranton Rd | San Diego | California | 92121-1761 | United States | brewpub | |
| Kilowatt Brewing | 7576 Clairemont Mesa Blvd | San Diego | California | 92111-1504 | United States | micro | |